研究方向:

1. 含氟功能分子的设计、合成及应用研究

2. 天然源化合物的功能性开发及应用研究

3. 手性光功能材料开发及反应性能研究

讲授课程:

有机合成化学、医用化学

学术兼职:

Frontiers in Catalysis评论编辑

学术成就:

长期从事含氟功能分子、天然来源分子及手性功能分子的设计、合成与应用研究，目前已在ACS Catal., Org. Lett., Chem. Commun., Org. Chem. Front., Chin. Chem. Lett., Adv. Synth. Catal., Adv. Funct. Mater.等期刊发表论文20余篇，入选ESI高被引论文1篇，获Organic Chemistry Frontiers 2020年度最佳论文奖。

科研项目:

新型多功能手性硼酸催化剂的设计、合成及其应用研究，浙江省自然科学基金青年项目，2020.01-2022.12，9万元，主持

基于惰性碳-氢键官能团化的含氟精细化学品的绿色合成，浙江省自然科学基金重点项目，2021.01-2024.12，30万元，参与

论著专利:

1. Jinshan Li†, Haohua Chen†, Rong Zhong, Lei Zhu, Saimei Liu, Hanfeng Ding, Jianguo Yang, Lei Wang, Yu Lan,* Zhiming Wang*. Perfluoroarene Interaction-Controlled Chiral Phosphoric Acid-Catalyzed Enantioselective Michael Addition of Difluoroenoxysilanes to Azadienes: a Combination of Experimental and Theoretical Studies. ACS Catal. 2022, 12, 9655−9663.

2. Haijian Wu, Peng Hong, Wenxue Xi, Jinshan Li*. Divergent Synthesis of gem-Difluorinated Oxa-Spirocyclohexadienones by One-Pot Sequential Reactions of p‑Hydroxybenzyl Alcohols with Difluoroenoxysilanes. Org. Lett. 2022, 24, 2488−2493.

3. Jinshan Li*, Saimei Liu, Rong Zhong, Yaqi Yang, Jinjing Xu, Jianguo Yang, Hanfeng Ding, Zhiming Wang*. Cascade Cyclization of Azadienes with Difluoroenoxysilanes: A One-Pot Formal [4 + 2] Approach to Fluorinated Polyfused Heterocycles. Org. Lett. 2021, 23, 9526−9532.

4. Jinshan Li*, Wenxue Xi, Saimei Liu, Yaqi Yang, Jianguo Yang, Hanfeng Ding, Zhiming Wang*. HFIP-catalyzed highly diastereoselective formal [4+2] cyclization to synthesize difluorinated multisubstituted chromans using difluoroenoxysilanes as C2 synthons. Chin. Chem. Lett. 2022, 33, 3007−3011.

5. Jinshan Li, Wenxue Xi, Saimei Liu, Chenxi Ruan, Xiaochun Zheng, Jianguo Yang, Lei Wang, Zhiming Wang*. HFIP-Catalyzed Difluoroalkylation of Propargylic Alcohols to Access Tetrasubstituted Difluoroalkyl Allenes. Org. Lett. 2021, 23, 7264−7269.

6. Jinshan Li, Saimei Liu, Rong Zhong, Yaqi Yang, Yuru He, Jianguo Yang, Yongmin Ma, Zhiming Wang*. Reversal of Regioselectivity in Nucleophilic Difluoroalkylation of α,β-Enones Employing In Situ-Formed Sterically Encumbered Silylium Catalyst. Org. Lett. 2021, 23, 5859−5864.

7. Jinshan Li, Wenxue Xi, Rong Zhong, Jianguo Yang, Lei Wang, Hanfeng Ding, Zhiming Wang*. HFIP-Catalyzed Direct Dehydroxydifluoroalkylation of Benzylic and Allylic Alcohols with Difluoroenoxysilanes. Chem. Commun. 2021, 57, 1050−1053.

8. Jinshan Li, Yixin Chen, Rong Zhong, Yonggang Zhang, Jianguo Yang, Hanfeng Ding, Zhiming Wang*. [3,3]-Sigmatropic Rearrangement/Haller–Bauer Reaction of Aryl Sulfoxides and Selenoxides with Difluoroenoxysilanes: Facile Access to CF2H-Containing Chalcogenides. Org. Lett. 2020, 22, 1164−1168.

9. Jinshan Li†, Kai Gao†, Ming Bian, Hanfeng Ding*. Recent advances in the total synthesis of cyclobutane-containing natural products. Org. Chem. Front. 2020, 7, 136−154.

10. Yixin Chen, Yurong Wang, Rong Zhong, Jinshan Li*. HFIP Promoted C3 Alkylation of Lawsone and 4-Hydroxycoumarin with Alcohols by Dehydrative Cross-Coupling. J. Org. Chem. 2020, 85, 10638−10647.

11. Meng-Yu Rong†, Jin-Shan Li†, Yin Zhou, Fa-Guang Zhang*, Jun-An Ma*. Catalytic Enantioselective Synthesis of Difluoromethylated Tetrasubstituted Stereocenters in Isoindolones Enabled by a Multiple-Fluorine System. Org. Lett. 2020, 22, 1164−1168.

12. Jin-Shan Li, Yong-Jie Liu, Shen Li, Jun-An Ma*. Chiral Phosphoric Acid-Catalyzed Direct Asymmetric Mannich Reaction of Cyclic C-Acylimines with Simple Ketones: Facile Access to C2-Quaternary Indolin-3-Ones. Chem. Commun. 2018, 54, 9151−9154.

13. Jin-Shan Li, Yong-Jie Liu, Guang-Wu Zhang, Jun-An Ma*. Catalytic Asymmetric Mukaiyama−Mannich Reaction of Cyclic C‑Acylimines with Difluoroenoxysilanes: Access to Difluoroalkylated Indolin-3-ones. Org. Lett. 2017, 19, 6364−6467.

14. Jin-Shan Li, Han-Feng Cui, Ke-Feng Zhang, Jing Nie, Jun-An Ma*. Phase-Transfer-Catalyzed Asymmetric Michael Addition of (Iminomethyl)phosphonates to α,β-Unsaturated Ketones: Access to α-Aminophosphonic Acid Derivatives. Eur. J. Org. Chem. 2017, 2017, 2545–2552.

15. Jinshan Li, Chuan-Fang Zhao, Jun Liu, Yu-Guo Du*. Total Synthesis of Proposed Cephalosporolides H and I. Tetrahedron 2015, 71, 3885–3889.

16. 李金山，王治明，吴海建，奚文学，一种合成α,α-二氟酮类化合物的方法，2023-03-07，中国，授权专利号：ZL 2020 1 1402001.0

合作交流:

李金山，氟醇催化反应研究，中国化学会第十六届全国氟化学会口头报告，2021-07-04