研究方向: 荧光传感

讲授课程: 《分析化学》、《仪器分析》、《化学与生物传感器》等

学术兼职: 《Polyhedron》客座编辑

学术成就: 主要研究领域为荧光探针的构建及其应用研究。研究成果在J. Hazard. Mater.、Sensor. Actuat. B Chem.、Food Chem.等国际主流学术刊物上发表SCI收录论文近30篇，申请国家发明专利2项。承担国家自然科学基金青年基金项目、海南省自然科学基金青年基金项目、海南省自然科学基金高层次人才项目等各级各类项目近10项。获海南省教育厅优秀研究生导师团队、永利集团优秀硕士学位论文指导教师、永利集团优秀本科毕业论文指导教师等奖励。担任《Polyhedron》客座编辑，负责 “antibiotic detection of MOFs”专刊的征集和评议工作。从事《分析化学》、《仪器分析》、《化学与生物传感器》等课程的讲授，参与了省级精品课程《仪器分析》的建设，负责“紫外-可见吸收光谱法”、“红外和拉曼光谱法”的录制及相关内容。

科研项目:

（1）国家自然科学基金青年基金项目，22004025，基于分子筛高效调控溶剂效应构建水相性能优异的D-π-A型荧光探针，2021-01至2023-12，24万元，主持。

（2）海南省自然科学基金高层次人才项目，122RC544，基于MOFs@ILs自组装材料的高灵敏四环素类抗生素荧光探针，2022-04至2025-03，10万元，主持。

（3）海南省自然科学基金青年基金项目，219QN154, “零背景结合信号放大”氟离子荧光传感系统的研究，2019-03至2021-12，5万元，主持。

（4）永利集团科研启动经费项目，KYQD(ZR)1926，MOF基H2O2比率荧光探针的构建与应用研究，2019-04至2023-10，100万元，主持。

（5）无机合成与制备化学国家重点实验室（吉林大学）开放课题，2020-28，MOF/苯乙烯菁主客体的构筑及其对BPO的比率荧光检测，2020-01至2021-12，3万元，主持。

（6）海南省院士团队创新中心，2022年，90万元，参与。

（7）海南省院士创新平台科研项目，YSPTZX202321，新型光致变色多孔功能材料的构建及应用探索研究，2023-04至2026-04，50万元，参与。

（8）横向技术服务项目，HD-KYH-2022207，高效检测材料与技术的探索和开发，2022-09至2026-12，50万元，参与。

论著专利:

(1) Yatian Cao, Xiaolong Gong, Le Li, Huihui Li*, Xuanming Zhang, Dong-Yu Guo*, Fuxiang Wang, Qinhe Pan*, Xylenol orange-modified CdTe quantum dots as a fluorescent/colorimetric dual-modal probe for anthrax biomarker based on competitive coordination, Talanta, 2023, 261, 124664.

(2) Xinyu Zheng, Shengming Chen, Bo Fu, Yatian Cao, Huihui Li*, Fuxiang Wang, Qinhe Pan*, Improved sensitivity of gold nanoclusters toward trypsin under synergistic adsorption of CdTe quantum dots, Microchemical Journal, 2023, 187, 108457.

(3) Yatian Cao, Ziqi Wang, Bo Fu, Huihui Li*, Xuanming Zhang, Dong-Yu Guo*, Le Li, Qinhe Pan*, Bifunctional ratiometric fluorescent probe for sensing anthrax spore biomarker and tetracycline at different excitation channels, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 285, 121915.

(4) Feng Gao, Senhao Lei, Huihui Li*, Shengming Chen, Shuixing Wu, Jiyang Li, Fuxiang Wang, Qinhe Pan*, Fluorescence color transformation of trans-4-[4-(N,N′-dimethylamino)styryl]pyridine-loaded UiO-66 for monitorable drug release, Journal of Photochemistry & Photobiology, A: Chemistry, 2023, 438, 114569.

(5) Taihe Han, Jinlong Zhang, Shuai Mu, Huihui Li, Shuangtong Wu, Xiaoyan Liu, Haixia Zhang*, ATP-triggered highly sensitive probes for super-resolution mitochondrial imaging and low-dose bioimaging, Journal of Materials Chemistry B, 2023, 11, 4776-4784.

(6) Bo Fu, Jiakun Chen, Yatian Cao, Huihui Li*, Feng Gao, Dong-Yu Guo*, Fuxiang Wang, Qinhe Pan*, Post-modified metal-organic framework as ratiometric fluorescence-scattering probe for trace ciprofloxacin residue based on competitive coordination, Sensors and Actuators B: Chemical, 2022, 369, 132261.

(7) Lu Ding, Yatan Cao, Huihui Li*, Fuxiang Wang, Dong-Yu Guo*, Weiting Yang, Qinhe Pan*, A ratiometric fluorescence-scattering sensor for rapid, sensitive and selective detection of doxycycline in animal foodstuffs, Food Chemistry, 2022, 373, 131669.

(8) Xinyu Zheng, Yang Yang, Feng Gao, Huihui Li*, Weikang Yang, Dong‑Yu Guo*, Shengming Chen, Qinhe Pan*, Enzyme‑free fuorescence determination of uric acid by combining CdTe quantum dots with metal-organic framework for signal amplifcation, Microchimica Acta, 2022, 189, 435.

(9) Weikang Yang, Xinyu Zheng, Feng Gao, Huihui Li*, Bo Fu, Dong-Yu Guo*, Fuxiang Wang, Qinhe Pan*, CdTe QDs@ZIF-8 composite-based recyclable ratiometric fluorescent sensor for rapid and sensitive detection of chlortetracycline, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 270, 120785.

(10) Haonan Zhao, Junfeng Zhang*, Xiaolian Lin, Huihui Li*, Qinhe Pan, Synthesis of 4-dimethylaminobenzyl chrysin ester-Zn fluorescent chemical sensor for the determination of Cr(VI) in water, Luminescence, 2022, 37, 72-81.

(11) Lu Ding, Yanyu Zhao, Huihui Li*, Qiujuan Zhang, Weiting Yang*, Bo Fu, Qinhe Pan*,  A highly selective ratiometric fluorescent probe for doxycycline based on the sensitization effect of bovine serum albumin, Journal of Hazardous Materials, 2021, 416, 125759.

(12) Bo Fu, Xinyu Zheng, Huihui Li*, Lu Ding, Fuxiang Wang, Dong-Yu Guo*, Weiting Yang, Qinhe Pan*, A highly stable, rapid and sensitive fluorescent probe for ciprofloxacin based on Al3+-enhanced fluorescence of gold nanoclusters, Sensors and Actuators B: Chemical, 2021, 346, 130502.

(13) Weikang Yang, Yonghang Yang, Huihui Li*, Duoyu Lin, Weiting Yang, Dongyu Guo*, Qinhe Pan*, Integration of Cd:ZnS QDs into ZIF-8 for enhanced selectivity toward Cu2+ detection, Inorganic Chemistry Frontiers, 2020, 7, 3718-3726.

(14) Huihui Li, Buan Fu, Weiting Yang*, Lu Ding, Yang Yang, Jiaxuan Dong, Fuxiang Wang, Qinhe Pan*, A recyclable fluorescent probe for picric acid detection in water samples based on inner filter effect, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 226, 117575.

(15) Huihui Li, Weiting Yang*, Qinhe Pan*, Integration of fluorescent probes into metal-organic frameworks for improved performances, RSC Advances, 2020, 10, 33879-33893.

(16) Lu Ding, Yanyu Zhao, Huihui Li*, Qiujuan Zhang, Weiting Yang*, Qinhe Pan*, A simple colorimetric probe for sensitive detection of Hg2+ based on MnO2 nanosheets and monothioglycerol, ChemistrySelect, 2020, 5, 13888-13894.

(17) Yang Yang, Jiaxuan Dong, Huihui Li*, Dongyu Guo*, Weiting Yang, Qinhe Pan*, AIE infinite coordination polymer for phosphate ion detection via aggregation state modulation, ChemistrySelect, 2020, 5, 11483-11488.

(18) Xiaodie Zhang, Guojian Ren*, Zhuopei He, Weiting Yang, Huihui Li, Yenan Wang, Qinhe Pan*, Xiaodong Shi*, Luminescent detection of Cr(VI) and Mn(VII) based on a stable supramolecular organic framework, Crystal Growth Design, 2020, 20, 6888-6895.

(19) Huihui Li, Fangxin Fu, Weiting Yang*, Lu Ding, Jiaxuan Dong, Yang Yang, Fuxiang Wang, Qinhe Pan*, A simple fluorescent probe for fast and sensitive detection of inorganic phosphate based on uranine@ZIF-8 composite, Sensors and Actuators B: Chemical, 2019, 301, 127110.

(20) Huihui Li, Wei Liu, Fengyuan Zhang, Xinyue Zhu, Liqiu Huang, Haixia Zhang*, Highly selective fluorescent probe based on hydroxylation of phenylboronic acid pinacol ester for detection of tyrosinase in cells, Analytical Chemistry, 2018, 90, 855-858.

(21) Huihui Li, Ling Zhu, Xinyue Zhu, Haixia Zhang*, Glucose detection via glucose-induced disaggregation of ammonium-modified tetraphenylethylene from polyanion, Sensors and Actuators B, 2017, 246, 819-825.

(22) Huihui Li, Cailing Yang, Xinyue Zhu, Haixia Zhang*, A simple ratiometric fluorescent sensor for fructose based on complexation of 10-hydroxybenzo[h]quinoline with boronic acid, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017, 180, 199-203.

(23) Jiaojiao Wang, Jingfeng Lan, Huihui Li, Xiaoyan Liu*, Haixia Zhang, Fabrication of diverse pH-sensitive functional mesoporous silica for selective removal or depletion of highly abundant proteins from biological samples, Talanta, 2017, 162, 380-389.

(24) Shuxia Wang, Huihui Li, Xiujuan Guan, Ting Cheng, Haixia Zhang*, Silica-boronate affinity material for quick enrichment of intracellular nucleosides, Talanta, 2017, 166, 148-153.

(25) Huihui Li, Ting Cheng, Shuxia Wang, Xinyue Zhu, Haixia Zhang*, High-efficiency extraction of nucleosides based on the combination of self-assembly ionic liquid layer and boronic acid-functionalized attapulgite, Talanta, 2016, 153, 71-78.

(26) Huihui Li, Shuqiang Zhu, Ting Cheng, Shuxia Wang, Bin Zhu, Xiaoyan Liu, Haixia Zhang*, Binary boronic acid-functionalized attapulgite with high adsorption capacity for selective capture of nucleosides at acidic pH values, Microchimica Acta, 2016, 183, 1779-1786.

(27) Ting Cheng, Huihui Li, Ying Ma, Xiaoyan Liu, Haixia Zhang*, Synthesis of boronic-acid-functionalized magnetic attapulgite for selective enrichment of nucleosides, Analytical Bioanalytical Chemistry, 2015, 407, 3525-3529.

(28) Xiaoyan Liu, Huihui Li, Zhigang Xu, Jialin Peng, Shuqiang Zhu, Haixia Zhang*, Development of hyperbranched polymers with non-covalent interactions for extraction and determination of aflatoxins in cereal samples, Analytica Chimica Acta, 2013, 797, 40-49.

(29) 李慧慧, 曹亚甜, 潘勤鹤, 炭疽杆菌孢子标志物荧光-紫外双模式检测方法, 发明专利, 2023-01-16, 中国, CN202310062746.4.

(30) 张海霞, 李慧慧, 一种检测食品中果糖的方法, 发明专利, 2018-11-13, 中国, ZL201611095215.1.

合作交流: 参加“中国化学会第32届学术年会”、“第二十一届全国有机分析及生物分析学术年会”、“中国材料大会2021”等学术会议。