研究方向:

1．有机磷化合物新的合成方法及其机理研究

2．过渡金属催化反应及其应用研究

3．药物分子与功能材料的设计开发

讲授课程：《化工热力学》、《化工过程分析与综合》、《精细化学品与工艺学》、《化工原理实验》、《生产实习》、《毕业实习》

学术成就: 海南自由贸易港D类人才，在Green Chem.、J. Org. Chem.、Organometallics、Dalton Trans.等国际高水平期刊发表SCI论文十余篇；主持国家自然科学基金青年基金项目、海南省自然科学基金青年基金项目、海南省自然科学基金高层次人才项目、永利集团科研启动经费等。

主要从事有机杂原子化合物新的合成方法及其机理研究、过渡金属催化反应及其应用研究。

科研项目:

1.国家自然科学基金青年基金项目，2023.01.01-2025.12.31，主持。

2.海南省自然科学基金高层次人才项目，2022.01.01-2024.12.30,10万元，主持。

3.海南省自然科学基金青年基金项目，2021.09-2024.06，5万元，主持。

4.永利集团科研启动基金项目，2020.11-2025.11，10万元，主持。

5. 国家级老员工创新训练项目，廉价金属催化醇和P(O)–H化合物脱水偶联合成含P–C键有机磷化合物研究，2021-2022，结题，指导老师。

6. 国家级老员工创新训练项目，过渡金属催化羧基导向C–H键活化构建C–P键反应的研究，2023-2024，在研，指导老师。

论著专利:

1.Chunya Liand Li-Biao Han*. Palladium-catalyzed solvent-free preparation of arylphosphonates ArP(O)(OAr)2from (ArO)3P via the Michaelis–Arbuzov rearrangement.Organometallics,2020,39, 3613-3617.

2.Chunya Li,Yuta Saga, Shun-ya Onozawa, Shu Kobayashi, Kazuhiko Sato, Norihisa Fukaya, and Li-Biao Han*. Wet and dry processes for the selective transformation of phosphonates to phosphonic acids catalyzed by Brønsted acids.J. Org. Chem.,2020,85, 14411–14419.

3.Chunya Li,Qi Wang, Jian-Qiu Zhang, Jingjing, Ye, Ju Xie, Qing Xu* and Li-Biao Han*. Water determines the products: an unexpected Brønsted acid-catalyzed PO-R cleavage of P(III) esters selectively producing P(O)–H and P(O)–R compounds.Green Chem.,2019,21, 2916-2922.

4.Chunya Li,Tieqiao Chen* and Li-Biao Han*. Iron-catalyzed clean dehydrogenative coupling of alcohols with P(O)–H compounds: a new protocol for ROH phosphorylation.Dalton Trans.,2016,45, 14893-14897.

5.Jian-Qiu Zhang, Jingzhuo Zhao,Chunya Li, Jingjing Ye, Li-Biao Han*.Conversion of

α‐hydroxy(2,4,6‐trimethylbenzyl)diphenylphosphine oxide to TPO: oxidationvsdecomposition.Phosphorus, Sulfur, and Silicon and the Relat. Elem.,2021,196, 207-210.

6. Kang Xiang, Shuo Zhang, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li, Kaiqiang Xua, Tieqiao Chen*.Tunable C–H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis.Org. Chem. Front.,2021,8, 2543-2550.

7. Xinyi Li, Long Liu, Tianzeng Huang, Zhi Tang,Chunya Li, Wenhui Li, Tao Zhang, Zhaohui Li, Tieqiao Chen*. Palladium-catalyzed decarbonylative sonogashira coupling of terminal alkynes with carboxylic acids.Org. Lett.,2021,23, 3304-3309.

8. Xue Liu, Long Liu, Tianzeng Huang, Jingjing Zhang, Zhi Tang,Chunya Li, Tieqiao Chen*. Trifluoromethylation of benzoic acids: an access to aryl trifluoromethyl ketones.Org. Lett.,2021,23, 4930-4934.

9. Yuanyuan Tang, Kuan Liu, Jinjin Zhang, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*. Palladium-catalyzed stereoselective difunctionalization of bicyclic alkenes with organoammonium salts and organoboronic compounds.J. Org. Chem.,2021,86, 11937-11947.

10. Tao Zhang, Kunyu Wang, Yuting Ke, Yuanyuan Tang, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*. Transition-metal-free and base promoted C–C bond formation via C–N bond cleavage of organoammonium salts.Org. Biomol. Chem.,2021,19, 8237-8240.

11. Ying Lin, Dongyang Li, Jingjing Zhang, Zhi Tang*, Long Liu, Tianzeng Huang,Chunya Li, Tieqiao Chen*. I2/NaH2PO2-mediated deoxyamination of cyclic ethers for the synthesis of N-aryl-substituted azacycles. New J. Chem.,2021,45, 21011-21014.

12. Kuan Liu, Bin Song, Qi Dang, Long Liu*, Jie Tang, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*.Walking Cations: Transition-Metal Free Benzyl Cation-Triggered sp2 C—H Phosphorylation and Etherification.Chin. J. Chem.,2022,40, 2933-2938.

13. Tianhao Xu, Xingyu Zhou, Xiong Xiao, Yan Yuan, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang and Tieqiao Chen*.Nickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols.J. Org. Chem.,2022,87, 13, 8672-8684.

14. Tianhao Xu, Wenhui Li, Kang Zhang, Yuhui Han, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang, and Tieqiao Chen*.Palladium-Catalyzed Decarbonylative Cyanation of Carboxylic Acids with TMSCN.J. Org. Chem.,2022,87, 11871-11879.

15. Tianhao Xu, Xiangbing Zhou, Yuhui Han, Liangwei Zhang, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang, Shungang Wan*, Tieqiao Chen*. Palladium-catalyzed stereo-selective three-component cis-1,2-arylalkynylation of bicyclic alkenes with aryltriflates and terminal alkynes.Tetrahedron Let.,2022,97,153799.

16. Tao Zhang, Runji Wang, Jiani Chen, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang and Tieqiao*. Base-promoted direct E-selective olefination of organoammonium salts with sulfones toward stilbenes and conjugated 1,3-dienes.Org. Biomol. Chem.,2022, 20, 4369-4375.

17. 李春娅，甘立广，樊晓璐，徐乐杰，陈铁桥，刘龙，黄添增，唐智. 一种有机膦氧类化合物及其合成方法，2023，专利，授权。

合作交流:

1.Chunya Li,Li-Biao Han.Water determines the selectivity: facile room temperature C-O cleavage of P(III) esters by Brønsted acids leading to a mild and efficient halide-Free Michaelis–Arbuzov rearrangement.日本化学会第99春季年会, 2019.03.16-2019.03.19(Oral Presentation).

2. Chunya Li, Li-Biao Han. Brønsted acid-catalyzed hydrolysis of phosphonates to phosphonic acids.日本第46回有機典型元素化学討論会, 2019.12.05-2019.12.07(Poster Presentation).